Dr Mistry studied medicine and surgery in Pretoria attaining his MBChB. Thereafter he completed his MMed in Surgery and Fellowship in Surgery FCS(SA) at the University of Pretoria. He completed his CVS(SA) (Certificate of Vascular Surgery) achieving a distinction and received the CJC Nel Award from VASSA. He was involved as a consultant at Chris Hani Baragwanath Hospital until 2022 and currently has private practices at Netcare Sunninghill Hospital, Life Fourways Hospital, Wits Donald Gordan Medical Centre and Johannesburg Surgical Hospital.

He has been affiliated with Wits University Department of Surgery since 2010 and is currently still actively involved. Dr Mistry has a special interest in complex endovascular aortic surgery and dialysis access surgery. He has presented at many congresses and been involved in many workshops related to vascular surgery. He has been an EXCO member of VASSA since 2010, Secretary and President Elect in 2023 and is the current President of the Society. He is also the President of the World Federation of Vascular Surgery and a Counsellor for the European Society of Vascular Surgery.